Predictive Toxicology

At AltheaDx, we combine multigene analysis with in vitro platforms for a fast economical solution for predicting compound liabilities early.

We have developed a single assay for monitoring the expression of the most critical genes in the cytochrome, phase II enzyme, and transporter families. Using this tool our clients can quickly determine the baseline of these critical elements in PKDM, or monitor the impact a compound has on their expression and thus on its pharmacokinetics, distribution and excretion.

 

Please read our publication, seen in the International Journal of Toxicology, documenting this powerful tool:

Gene Expression Analysis of Troglitazone Reveals Its Impact on Multiple Pathways in Cell Culture: A Case for In Vitro Platforms Combined with Gene Expression Analysis for Early (Idiosyncratic) Toxicity Screening.